flumethasone injection half life
Flumethasone is a glucocorticoid that is FDA-approved for use in horses. Branded under the name Flucort®, it is a chemical modification of prednisolone. Which possesses greater anti-inflammatory and gluconeogenic properties than the parent compound when compared on an equivalent basis. Once use in small animal veterinary practices, it is no longer commonly used in small animals. 3 Flumethasone is long-acting and 15 times more potent than hydrocortisone. Flumethasone injection half life, flumethasone injection for horses, flumethasone injection
Flumethasone is recommended for various rheumatic. Allergic, dermatologic and other disease states which are known to be responsive to the anti-inflammatory corticoids. It is recommended for parenteral administration using various routes depending on the animal species under treatment. The intravenous (IV) use of flumethasone may be indicated when a rapid method of administration is desired such as in toxemias or shock or shock-like states.
flumethasone injection
Injectable flumethasone is available commercially as a free steroid alcohol solution. While flumethasone does not work as rapidly as the corticosteroid phosphate and succinate esters (methylprednisolone sodium succinate. Prednisolone sodium succinate, or dexamethasone sodium phosphate). It can be given either IM or IV and is useful for acute reactions such as insect bite hypersensitivity or vaccine reactions.4
Flumethasone is labeled in horses as indicated for: 1) Musculoskeletal conditions due to inflammation. Where permanent structural changes do not exist, such as bursitis, carpitis, osselets, and myositis. Following therapy, an appropriate period of rest should be institute to allow a more normal return to function of the affected part. 2) Allergic states such as urticaria (hives) and insect bites.3
flumethasone injection for horses
In dogs, flumethasone injection (Flucort®) is labeled for. 1) musculoskeletal conditions due to inflammation of muscles or joints and accessory structures. Where permanent structural changes do not exist, such as arthritis, osteoarthritis, intervertebral disc syndrome and myositis. In septic arthritis, appropriate antibacterial therapy should be concurrently administered. 2) Certain acute and chronic dermatoses of varying etiology to help control the pruritus, irritation. And inflammation associated with these conditions. The drug has proven useful in otitis externa in conjunction with topical medication for similar reasons. 3) Allergic states such as urticaria and insect bites.
The active ingredient of FLUMETHASONE is flumethasone which occurs as a white to creamy white, odorless, crystalline powder. The appearance of FLUMETHASONE is a clear, colorless to slightly yellowish, mobile liquid. Experimental Studies: The acetate of flumethasone has been report to have approximately 700 times the activity of hydrocortisone in the rat liver glycogen disposition assay 1,2. Veterinary experimental studies utilizing eosinophil depression in normal dogs and blood glucose levels. And eosinophil depression in normal cattle as parameters of drug activity in comparison tests involving dexamethasone. And prednisone, suggest gluconeogenic and anti-inflammatory potencies for flumethasone of the following approximate order: