Onsior Injection

Onsior injection is a prescription non-steroidal anti-inflammatory drug (NSAID) containing robenacoxib, manufactured by Elanco Animal Health. Onsior® tablets and injections are the only FDA-approved oral NSAID for cats and the #1 feline NSAID brand in the US. ONSIOR (robenacoxib) injection is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) of the coxib class.

Active Ingredient: Robenacoxib

Molecular Structure and Classification:

The molecular weight of robenacoxib is 327.28. The empirical formula is C16-H13-F4-NO2. Robenacoxib is [5-Ethyl-2-(2,3,5,6-tetrafluoro-phenylamino)-phenyl

Coxib Class Properties:

COX-2 Selective: Preferential inhibition of COX-2 enzyme

Anti-inflammatory: Reduces inflammation and swelling

Analgesic: Provides effective pain relief

Non-narcotic: Non-addictive pain management option

Formulation Specifications

Injectable Solution:

Each mL of this clear sterile solution for injection contains 20 mg robenacoxib, 350 mg polyethylene glycol 400, 120 mg ethanol, 100 mg poloxamer 188, 1 mg sodium metabisulfite; citric acid and sodium hydroxide are used for pH adjustment. Buy Onsior injection online

Onsior Injection Available Presentations:

Concentration: 20 mg robenacoxib per mL

Packaging: 20 mL multidose vial

Appearance: Clear, sterile solution for injection

Species-Specific Applications

Cats:

ONSIOR (robenacoxib) is for the control of postoperative pain and inflammation associated with orthopedic surgery (declaw), ovariohysterectomy (spay) and castration (neuter) in cats greater than or equal to 5.5 pounds (2.5 kg) and greater than or equal to 4 months of age; for a maximum of 3 days.

Feline Indications:

Post-surgical Pain: Orthopedic procedures, spay/neuter operations

Declawing: Pain management following declawing procedures

Short-term Use: Maximum 3-day treatment duration

Weight Restriction: Do not use in cats less than 5.5 lbs.

Dogs:

Onsior injection is also approved for use in dogs for similar postoperative pain management applications.

Canine Applications:

Postoperative Pain: Following various surgical procedures

Soft Tissue Surgery: Pain control after soft tissue operations

Orthopedic Surgery: Pain management for bone and joint procedures

Pharmacokinetics

Cats:

In a crossover design, robenacoxib was administered IV, SC, and orally (experiment 1) and orally (experiment 2) to cats with different feeding regimens. Blood robenacoxib concentrations were assayed, with a lower limit of quantification of 3 ng/mL.

Dogs:

The pharmacokinetics of robenacoxib injection does not differ between male and female dogs, and is linear over the range of 0.25-4 mg/kg in dogs.

Onsior Injection Key Pharmacokinetic Properties:

Linear Kinetics: Predictable dose-response relationship

Gender Independence: No difference between male and female animals

Multiple Routes: Can be administered IV, SC, or orally

Rapid Action: Quick onset of anti-inflammatory effects

Clinical Efficacy

Pain Management Studies:

Robenacoxib, administered at a target dose of 2 mg/kg prior to surgery and once daily for two postoperative days, produced better analgesia than a placebo: analgesia was measured in terms of the need for rescue analgesia after surgery.

Safety Profile:

No significant changes in the mean values for hematology were observed during clinical studies, indicating good safety tolerance.

It is concluded that alternating regimens of robenacoxib tablets and injection (Onsior™) were well tolerated in healthy young dogs when administered once a day.

Onsior Injection Dosing Guidelines

Administration Frequency:

Onsior® is designed to be given every 24 hours and should provide pain relief to your pet for that timeframe. Buy Onsior injection online

Clinical Dosing:

Your cat should not receive more than one dose a day, for the prescribed treatment period.

Professional Dosing Considerations:

Weight-Based Dosing: Calculated according to patient body weight

Once Daily: 24-hour dosing interval

Limited Duration: Short-term use only (maximum 3 days in cats)

Professional Assessment: Veterinary evaluation for appropriate dosing

Safety Considerations

Long-Term Safety:

Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations demonstrated acceptable safety profiles in extended studies.

General NSAID Precautions:

Monitor for gastrointestinal effects

Assess renal and hepatic function

Avoid concurrent use with other NSAIDs

Consider individual patient sensitivity

Age and Size Restrictions:

Cats: Minimum 4 months of age and 5.5 pounds body weight

Professional Assessment: Veterinary evaluation for suitability

Prescription Requirements

Legal Status:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Buy Onsior injection online

Professional Oversight:

Veterinary prescription required

Professional administration or supervision

Patient assessment before and during treatment

Monitoring for therapeutic response and adverse effects

Onsior Injection Clinical Benefits

Postoperative Care:

Effective Pain Control: Superior analgesia compared to placebo

Reduced Rescue Medication: Less need for additional pain relief

Improved Recovery: Enhanced comfort during healing period

Convenient Dosing: Once-daily administration

Interchangeable Use:

The injectable and tablet forms can be used interchangeably, providing flexibility in treatment protocols and allowing for seamless transition between hospital and home care. Buy Onsior injection online

Onsior injection represents a valuable tool in veterinary pain management, offering effective, safe, and convenient postoperative pain control for cats and dogs when used under appropriate professional veterinary supervision.