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Adrenocorticotropic hormone (ACTH), also known as corticotrophin, is a polypeptide tropic hormone produce and secreted by the anterior pituitary gland. It is an important component of the hypothalamic pituitary adrenal axis and is often produce in response to biological. Its principal effects are increased production and release of corticosteroids. Buy ACTH Gel Injection online usa, Order ACTH Gel Injection online Utah, ACTH Gel Injection price in Vermont, ACTH Gel Injection for sale in Virginia, Buy ACTH Gel Injection without prescription Washington, where can i order ACTH Gel Injection online Wisconsin, best place to order ACTH Gel Injection in Texas, Order ACTH Gel Injection near me South Carolina
ACTH stimulates secretion of the glucocorticoid steroid hormones from the adrenal cortex cells, especially in the zona fasciculata of adrenal glands. ACTH acts by binding to cell surface ACTH receptors, which are located primarily on the adrenocortical cells of the adrenal cortex. The ACTH receptor is a seven membrane spanning G protein- oupled receptor. Upon ligand binding, the receptor undergoes conformation changes to stimulate the enzyme adenylyl cyclase, which does lead to an increase in intracellular cAMP and subsequent activation of protein kinase.
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ACTH influences steroid hormone secretion by both rapid short term mechanisms that takes place within minutes and slower long term actions. The rapid actions of ACTH include stimulation of cholesterol delivery to the mitochondria where P450scc enzyme is located. P450scc catalyzes the first step of steroidogenesis and is cleavage of the side chain of cholesterol. ACTH also stimulates lipoprotein uptake into the cortical cells. This increases the bioavailability of cholesterol in cells of the adrenal cortex.
The long term actions of ACTH include stimulation of the transcription of the genes coding for steroidogenic enzymes, especially the P450scc, the steroid 11?-hydroxylase along with their associated electron transfer proteins. The effect is observed over several hours.
In addition to steroidogenic enzymes, ACTH also enhances transcription of the mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems. These actions may actually be necessary to supply the enhance energy needs of adrenocortical cells stimulated by ACTH. Buy ACTH Gel Injection online usa, Order ACTH Gel Injection online Utah, ACTH Gel Injection price in Vermont, ACTH Gel Injection for sale in Virginia, Buy ACTH Gel Injection without prescription Washington, where can i order ACTH Gel Injection online Wisconsin, best place to order ACTH Gel Injection in Texas, Order ACTH Gel Injection near me South Carolina