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AL Namoos vasodilating prostaglandins are protective, ensuring arterial and renal vasoconstriction. The loss of this protective effect becomes important in patients with impaire renal function. Patients predisposed to analgesic nephropathy include geriatric patients, patients suffering from heart, kidney or liver disease, patients in hypovolemic states (shock and dehydration), and patients receiving nephrotoxic (aminoglycosides, for example) or nephroactive (diuretic) drugs.
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