toltrazuril for goats
DESCRIPTION:
Toltrazuril is the result of extensive research efforts to help treat EPM (equine protozoal myeloencephalitis), which causes a multitude of effects that manifest in a variety of symptoms. Our solution represents a new standard in coccidiosis control, belonging to the chemical group of symmetric triazinons not related to any other anticoccidial drug currently in use in veterinary medicine. Our 5% solution affects all intracellular structures of the one-celled protozoan parasite called Sarcocystis neurona. Toltrazuril is highly effective and has demonstrated the following benefits:
-prevents and reduces the severity of lesions
-stops oocyst shedding
-improves growth rate
-improves feed conversion
HOW IT WORKS:
Our Toltrazuril 5% solution is suitable for both therapy and metaphylaxis, and acts as an effective tool for controlling coccidia-related problems. By damaging the intracellular developmental stages of Coccidia, toltraturazil affects schizonts, microgametes, and macrogametes without damaging the cell tissue of the host animal. Findings from studies suggest the drug interferes with the division of the nucleus and the activity of mitochondria, which is responsible for respiratory metabolism in the parasite. In the magrometes, toltrazuril damages wall-forming bodies, and in all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum. Toltrazuril does not interfere with immune development, and usually does not require follow-up treatment, even in advanced infections (after three to five days). However, the efficacy of the drug is independent from the severity of the infection.
toltrazuril for goats
Toltrazuril is quite lipid soluble so absorption and distribution into tissue is very good. As Toltrazuril only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. To be soluble in water, the product undiluted is very alkaline, pH 11.4. Direct oral dosing of the undiluted product is very irritating to mucous membranes and will cause immediate vomiting. Make sure you are using the correct formulation.
Toltrazuril is a relatively new treatment that may actually cure coccidiosis, instead of just suppressing it. The drug is readily available in Canada and Australia, but not the US. While other drugs have been used to control Coccidia infections, they do not provide a cure, and the animal may continue to be infectious to other animals.
FOR USE WITH CATS:
DO NOT use the 2.5% solution sold as a pigeon remedy, as it can be caustic to the mucus membranes of cats.
DO NOT use this drug in pregnant cats as the teratogenic effects of this drug has not been adequately research as of now.
The dose of Toltrazuril 5% suspension is 20 mg/kg, or 10 mg/0.2 mL per pound. In a published study, a single dose of Toltrazuril cured coccidiosis in puppies, as long as adequate environmental cleanup is perform. However, it is recommend to repeat the treatment weekly for a couple of weeks. It is CRITICAL to clean the environment to rid it of coccidia. This drug is most effective when it is use at the age of 4-6 weeks to PREVENT coccidia infection in kittens.
Cystoisospora is pathogenic for puppies and can induce severe disease. Natural infections are common in conventional dog breeding facilities. Toltrazuril treatment is suitable for controlling cystoisosporosis under experimental and field conditions. A single oral treatment for puppies in the 3rd/4th week of age is recommend.”
toltrazuril for goats
It is very difficult to judge when a kitten is infect, which is why administration prior to clinical symptoms is recommend. The intent is to kill the protozoa before there is damage to the villi to clear the infection. In this way, the kittens will not develop the normal clinical signs of diarrhea. If you can identify oocysts in fecal exam, the protozoa has completed its reproductive cycle. The drug can not penetrate the oocyst wall to kill this stage, but treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril will kill single cell stages that have not reproduced sexually yet.
toltrazuril for cats
ADDITIONAL INFORMATION:
The below information was taken from a journal abstract post to the Fanciershealth Yahoogroups list in 2001: Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. A Daugschies, HC Mundt, V Letkova Parasitology Research, 2000, Vol 86, Iss 10, pp 797-799
“Coccidia of the genus Cystoisospora cause mild to severe diarrhoea in dogs. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Twenty-four puppies were experimentally infec each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. Three groups of six puppies were treat 3 dpi with 10, 20 or 30 mg/kg body weight of toltrazuril suspension (5%); the remaining six puppies serve as non-treated controls. Toltrazuril suspension or microgranulate were give once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Oocyst excretion and clinical data were record. toltrazuril for goats