marbocyl 10 100ml

Marbofloxacin is a synthetic second generation fluoroquinolone currently used as broad-spectrum bactericidal antibiotic in veterinary therapeutics. Fluoroquinolone antibiotics are potent drugs that target bacterial DNA gyrases – mostly in Gram(−) – and TopIV in Gram(+) microorganisms. marbocyl 10 100ml

Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the brand names Marbocyl, Forcyl, Marbo vet and Zeniquin.

marbocyl 10 100ml Active Ingredient and Composition

Each 100ml contains marbofloxacin 10g, monothioglycerol 0.1g, metacresol 0.2g and disodium edetate 0.01g.

This represents a 10% concentration of marbofloxacin (100mg/ml).

Target Species and Indications

Cattle:

Cattle: Indicated in the treatment of respiratory infections caused by susceptible strains of organisms. It is also indicated in the treatment of acute E.coli mastitis.

In cattle, for the treatment of respiratory infections caused by P.multocida, M.haemolytica and M.bovis and treatment of acute mastitis caused by E.coli.

Treatment of respiratory infections caused by sensitive strains of Pasteurella multocida, Mannheimia (Pasteurella) haemolytica and Mycoplasma bovis. Treatment of acute mastitis caused by E.coli strains sensitive to marbofloxacin during the lactation period.

Pigs:

Pigs: Indicated in the treatment of Metritis Mastitis Agalactia syndrome caused.by susceptible organisms.

Dogs and Cats:

Marbofloxacin is a common drug used by veterinarians to treat bacterial infections in cats and dogs.Marbofloxacin can be prescribed by veterinarians to treat urinary, skin, and soft tissue infections in dogs and cats.

marbocyl 10 100ml Dosage and Administration

Cattle:

Cattle: 2 mg of marbofloxacin/kg body weight (corresponding to 1 ml Marbosan-100 per 50 kg body weight) as a subcutaneous or an intramuscular injection once daily for 3 – 5 days. The treatment for acute mastitis is 3 days intramuscularly. The first injection may be administered intravenousy.

Administration Routes:

Subcutaneous injection

Intramuscular injection

Intravenous injection (for first dose in some cases)

Treatment Duration:

General infections: 3-5 days

Acute mastitis: 3 days

Mechanism of Action

Marbofloxacin prevents bacterial cells from replicating and rapidly causes cell death. In its class, marbofloxacin remains a more potent option due to how the body metabolizes the drug.

Its mechanism of action is not thoroughly understood, but it is believed to be similar to the other fluoroquinolones by impairing the bacterial DNA gyrase which results in rapid bactericidal activity.

Age Restrictions and Contraindications

Dogs:

This medication should not be administered to small and medium breed dogs less than 8 months of age, large breed dogs less than 12 months of age and giant breed dogs less than 18 months of age.

This restriction is due to potential effects on developing cartilage in young, growing animals.

Spectrum of Activity

Marbofloxacin is effective against:

Gram-positive bacteria: Including Staphylococcus species, Streptococcus species

Gram-negative bacteria: Including E. coli, Pasteurella species, Mannheimia haemolytica

Mycoplasma species: Including M. bovis

Various other susceptible aerobic bacteria

marbocyl 10 100ml Pharmacological Properties

Bactericidal action: Rapidly kills bacteria rather than just inhibiting growth

Good tissue penetration: Achieves therapeutic levels in various tissues

Broad spectrum: Effective against diverse bacterial pathogens

Once daily dosing: Convenient administration schedule

Special Considerations

Food-Producing Animals:

Appropriate withdrawal periods must be observed before slaughter

Milk withdrawal periods required for lactating cattle marbocyl 10 100ml

Specific withdrawal times vary by jurisdiction and should be confirmed on product labeling

Storage Requirements:

Store according to manufacturer’s instructions

Typically requires storage below 25°C

Protect from light

Do not freeze

Clinical Advantages

High potency: More effective than many other fluoroquinolones

Convenient dosing: Once daily administration

Broad spectrum: Covers major veterinary pathogens

Good bioavailability: Effective tissue and fluid concentrations

Rapid onset: Quick bactericidal activity

Important Safety Notes

Should only be used under veterinary supervision

Complete the full course of treatment even if symptoms improve

Monitor for adverse reactions

Use appropriate injection techniques to minimize tissue irritation

Consider bacterial culture and sensitivity testing when possible marbocyl 10 100ml

Regulatory Status

Marbocyl 10 is a prescription-only veterinary medicine (POM-V) requiring veterinary oversight for legal purchase and use. It’s subject to specific regulations regarding withdrawal periods in food-producing animals.

Professional Use

This medication should be used by qualified veterinarians or under direct veterinary supervision, with proper attention to:

Accurate dosing based on body weight

Appropriate injection techniques

Monitoring for therapeutic response

Compliance with withdrawal periods

Recognition and management of potential adverse effects

Marbocyl 10 100ml represents a potent and versatile fluoroquinolone antibiotic option for treating serious bacterial infections in cattle, pigs, and other veterinary species, requiring careful professional management to ensure safe and effective use.