NovoRapid Insulin Pen

NovoRapid is a rapid-acting insulin analog (insulin aspart) manufactured by Novo Nordisk, available in convenient pre-filled pen devices. NovoRapid, also known as insulin aspart and Novolog, is a Novo Nordisk fast-acting analog insulin. Preventing this self-association keeps the insulin in dimer and monomer form, making them absorb better and faster, resulting in faster onset, peak and less duration.

Active Ingredient: Insulin Aspart

Molecular Structure:

How insulin aspart differs from human insulin is the change at position #28 in the B insulin chain; the natural amino acid present is Proline–insulin aspart substitutes aspartic acid for it. This substitution reduces the tendenc for self-association, allowing for faster absorption and action.

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  Pharmacokinetic Profile:

Aspart: This product’s onset of action is very rapid; providing quick glucose control after administration.

Key Characteristics:

Onset: Very rapid (within 10-20 minutes)

Peak Action: 1-3 hours

Duration: 3-5 hours

Absorption: Faster than regular insulin due to molecular modification

Available Pen Devices

FlexPen and FlexTouch:

NovoRapid is available in two primary pen delivery systems:

FlexPen: Pre-filled, disposable insulin pen

FlexTouch: Advanced pre-filled pen with improved design

Concentration: U-100 insulin (100 units per mL)

Volume: Typically 3 mL cartridges

Veterinary Applications

Canine and Feline Diabetes:

NovoLog is a U-100 rapid-acting insulin. U-100 means that each milliliter of insulin is divided into 100 dosing units. Insulin is prescribed to dogs and cats with diabetes mellitus to help lower their blood sugar. Insulin is an ongoing, supportive treatment for diabetes.

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Primary Uses:

Diabetes Mellitus Management: Primary treatment for diabetic dogs and cats

Diabetic Ketoacidosis (DKA): Emergency treatment protocols

Postprandial Control: Managing post-meal glucose spikes

Intensive Management: Situations requiring precise glucose control

Clinical Advantages:

Rapid Onset: Quick action for immediate glucose control

Flexible Timing: Can be given closer to meal times

Precise Dosing: Pen device allows accurate dose delivery

Convenience: Easy administration for pet owners

Dosing Considerations

General Principles:

While veterinary-specific insulin products like Vetsulin are typically preferred, rapid-acting human insulins like NovoRapid may be used in specific clinical situations under veterinary supervision.

Dosing Factors:

Species: Dogs vs. cats have different insulin sensitivities

Body Weight: Dosing typically calculated per kg body weight

Individual Response: Varies significantly between animals

Concurrent Conditions: Other diseases may affect insulin requirements

Professional Oversight:

Insulin therapy is still the primary therapy for all diabetic dogs and cats. Several insulin options are available for each species, including veterinary registered products and human insulin preparations. The insulin chosen depends on the specific patient needs and clinical circumstances.

Administration Guidelines

Pen Device Use:

Preparation: Check insulin appearance and pen function

Priming: Remove air bubbles before injection

Dosing: Select prescribed dose using pen mechanism

Injection: Subcutaneous injection in appropriate sites

Post-injection: Proper disposal and storage

Injection Sites:

Dogs: Scruff of neck, flank areas

Cats: Similar areas with site rotation

Technique: Proper subcutaneous injection depth

Rotation: Prevent lipodystrophy through site rotation

Clinical Monitoring

Blood Glucose Monitoring:

Home Monitoring: Blood glucose curves

Veterinary Assessment: Regular check-ups

Adjustment: Dose modifications based on response

Signs: Monitor for hypo/hyperglycemia symptoms

Emergency Situations:

CRI protocol: 1.1U/kg of regular or lispro insulin added to 48mL 0.9% NaCl or or Ringer’s solution · Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats.

Safety Considerations

Hypoglycemia Risk:

Rapid Action: Quick onset increases hypoglycemia risk

Monitoring: Close observation after administration

Emergency Treatment: Glucose supplementation readily available

Signs: Weakness, trembling, collapse

Storage Requirements:

Refrigeration: Store unopened pens at 2-8°C

In-Use: Can be kept at room temperature for limited time

Light Protection: Protect from direct sunlight

Expiration: Check dates and replace as needed

Comparison with Veterinary Insulins

Veterinary-Specific Options:

In dogs, the labeled starting Vetsulin dose is 0.5 IU insulin/kg of body weight. This dose should be given once daily concurrently with or right after a meal.

Vetsulin and VetPen for Cats and Dogs is an FDA-approved insulin to manage diabetes in pets.

When NovoRapid May Be Used:

Specific Clinical Needs: Rapid action required

Veterinary Recommendation: Professional assessment indicates benefit

Availability Issues: When veterinary insulins unavailable

Cost Considerations: Economic factors in some cases

Professional Consultation Required

Veterinary Oversight:

Prescription Required: Professional assessment essential

Monitoring Protocol: Regular follow-up appointments

Dose Adjustments: Based on clinical response

Emergency Planning: Hypoglycemia management protocols

Client Education:

Proper Technique: Pen device operation

Storage Handling: Maintaining insulin integrity

Monitoring Signs: Recognizing complications

Emergency Response: Hypoglycemia treatment

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NovoRapid insulin pens represent a sophisticated delivery system for rapid-acting insulin that can be valuable in veterinary diabetes management when used under appropriate professional supervision, particularly in situations requiring precise, rapid glucose control in diabetic dogs and cats.