Depo Medrol For Dog
The usual intramuscular dose for horses is 200 mg repeated as necessary. For maintenance therapy in chronic conditions, initial doses should be reduced gradually until the smallest effective (ie, individualized) dose is established. MEDROL® Tablets containing methylpred¬nisolone may also be used for maintenance in dogs and cats, administered according to the recommended dose. Depo Medrol For Dogs
When treatment is to be withdrow after prolong and intensive therapy. The dose should be reduce gradually.
If signs of stress are associate with the condition being treat, the dose should be increase. If a rapid hormonal effect of maximum intensity is require, as in anaphylactic shock, the intravenous administration of highly soluble SOLU-DELTA-CORTEF Sterile Powder containing prednisolone sodium succinate is indicate.
INTRASYNOVIAL
Methylprednisolone acetate, a slightly soluble ester of methylprednisolone, is capable of producing a more prolonged local anti-inflammatory effect than equimolar doses of hydrocortisone acetate. Following intrasynovial injection, relief from pain may be experience within 12 to 24 hours. The duration of relief varies, but averages three to four weeks, with a range of one to five or more weeks. Injections of methylprednisolone acetate have been well tolerate.
Intrasynovial (intra-articular) injections may occasionally result in an increased localized inflammatory response.
Intrasynovial injection is recommend as an adjuvant to general therapeutic measures to effect suppression of inflammation in one or a few peripheral structures when (1) the disease is limite to one or a few peripheral structures. (2) the disease is widespread with one or a few peripheral structures actively inflame. (3) systemic therapy with other corticoids or corticotropin controls all but a few of the more actively involve structures. (4) systemic therapy with cortisone, hydrocortisone, or corticotropin is contraindicate. (5) joints show early but actively progressing deformity (to enhance the effect of physiotherapy and corrective procedures); and. (6) surgical or other orthopedic corrective measures are to be or have been done.
The action of DEPO-MEDROL Sterile Aqueous Suspension injected intrasynovially appears to be well localize since significant metabolic effects characteristic of systemic administration of adrenal steroids have not been observe. In a few instances mild and transient improvement of structures other than those injecte have been report. No other systemic effects have been note. However, it is possible that mild systemic effects may occur following intrasynovial administration, and this possibility is greater the larger the number of structures injecte and the higher the total dose employ.
Procedure for Intrasynovial Injection
The anatomy of the area to be inject should be review in order to assure that the suspension is properly place and to determine that large blood vessels or nerves are avoid. The injection site is located where the synovial cavity is most superficial. The area is prepar for aseptic injection of the medicament by the removal of hair and cleansing of the skin with alcohol or Mercresin® tincture. A sterile 18- to 21-gauge needle for horses, 20- to 22-gauge needle for dogs, on a dry syringe is quickly inserte into the synovial space and a small amount of synovial fluid withdrawn.
If there is an excess of synovia and more than 1 mL of suspension is to be inject, it is well to aspirate a volume of fluid comparable to that which is to be inject. With the needle in place, the aspirating syringe is remove and replace by a second syringe containing the proper amount of suspension which is then inject. In some animals a transient pain is elicite immediately upon injection into the affected cavity. This pain varies from mild to severe and may last for a few minutes up to 12 hours. After injection, the structure may be move gently a few times to aid mixing of the synovial fluid and the suspension. The site may be cover with a small sterile dressing.