Meflosyl 50ml Injection

Meflosyl 50ml Injection is a veterinary injectable solution containing flunixin meglumine as the active ingredient, formulated as a 5% solution (50mg/ml).

In the USA the trade names are Banamine, Flunixamine, Citation, Equileve, and Meflosyl Solution. MEFLOSYL 5% SOLUTION FOR INJECTION. indicates this is a 5% concentration flunixin meglumine solution.

 

Active Ingredient

Flunixin Meglumine – A potent non-steroidal anti-inflammatory drug (NSAID) belonging to the pyrazolone class of medications.

Concentration

5% solution = 50mg flunixin meglumine per milliliter

Target Species

Indicated for the intravenous administration to cattle and horses.

Primary Indications

Meflosyl 50ml Injection In Horses:

For use in musculo-skeletal disorders, the recommended dose rate is 1.1 mg flunixin/kg.

Common uses include:

Musculoskeletal pain and inflammation

Colic management

Post-surgical pain control

Inflammatory conditions

Fever reduction

In Cattle:

Pain and inflammation associated with various conditions

Post-surgical analgesia

Respiratory disease support

Mastitis-associated inflammation

Meflosyl 50ml Injection Dosage and Administration

Horses:

the recommended dose rate is 1.1 mg flunixin/kg.

This translates to approximately 0.022 ml per kg body weight

For a 500kg horse: approximately 11ml per dose

Administration Routes:

Indicated for the intravenous administration (preferred route) It can also be used intramuscularly or intravenously, although because it is very irritating to tissue, the IV route is preferred.

Frequency:

Typically administered once or twice daily

Treatment duration should be limited to minimize side effects

Mechanism of Action

Flunixin meglumine works by:

Inhibiting cyclooxygenase (COX) enzymes

Reducing prostaglandin synthesis

Providing anti-inflammatory, analgesic, and antipyretic effects

Particularly effective against endotoxin-induced inflammation

Important Safety Warnings

Tissue Irritation:

because it is very irritating to tissue, the IV route is preferred over intramuscular injection.

Nephrotoxicity Risk:

Concurrent administration of potentially nephrotoxic drugs should be avoided.

Special Population Considerations:

Dosages are usually reduced for ponies, who are more at-risk for NSAID side effects, as well as horses with decreased liver or kidney function (such as older horses).

Side Effects and Adverse Reactions

Common NSAID Side Effects:

Gastrointestinal ulceration

Kidney dysfunction

Liver toxicity (with prolonged use)

Delayed wound healing

Interference with platelet function

Specific to Flunixin:

Tissue necrosis if given intramuscularly

Potential for severe colic if overdosed

Depression and inappetence

Contraindications

Known hypersensitivity to flunixin or other NSAIDs

Severe kidney or liver disease

Gastrointestinal ulceration

Bleeding disorders

Dehydrated animals

Pregnancy (especially late term) – use with caution

Drug Interactions

Other NSAIDs (avoid concurrent use)

Corticosteroids (increased GI ulcer risk)

Anticoagulants (enhanced bleeding risk)

Nephrotoxic drugs (increased kidney damage risk)

Aminoglycosides (enhanced nephrotoxicity)

Withdrawal Times

For food-producing animals (cattle):

Meat withdrawal times must be observed

Milk withdrawal periods required for lactating cattle

Specific times vary by jurisdiction – consult product labeling

Storage and Handling

Store at controlled room temperature

Protect from light

Do not freeze Meflosyl 50ml Injection

Use within specified time after opening

Maintain sterility for injection

Clinical Considerations

Pre-treatment Assessment:

Evaluate hydration status

Check kidney and liver function

Assess for concurrent medications

Consider patient age and condition

Monitoring During Treatment:

Hydration status

Appetite and behavior

Kidney function (with prolonged use)

Signs of GI upset

Meflosyl 50ml Injection Administration Technique:

Use strict aseptic technique

Administer slowly intravenously

Ensure proper needle placement

Monitor injection site Meflosyl 50ml Injection

Therapeutic Benefits

Rapid onset: Quick pain relief and anti-inflammatory action

Effective analgesia: Particularly good for visceral pain

Anti-endotoxic effects: Beneficial in septic conditions

Fever reduction: Effective antipyretic properties

Professional Use Guidelines

Should only be used under veterinary supervision

Proper diagnosis essential before treatment

Use lowest effective dose for shortest duration

Ensure adequate hydration before and during treatment

Monitor for adverse effects throughout therapy

Package Information

The 50ml vial provides multiple doses depending on animal size and dosing requirements, making it suitable for both individual animal treatment and herd/group management.

Meflosyl 50ml injection represents a potent and effective NSAID option for managing pain and inflammation in horses and cattle, requiring careful attention to proper dosing, administration technique, and patient monitoring to ensure safe and effective use.